Sequelae of Lassa Fever: Postviral Cerebellar Ataxia

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Cerebellar ataxia in enteric fever.

In a study of enteric fever, cerebellar ataxia was found to be the commonest neurological manifestation, second only to toxic delirium. Excluding toxic delirium (found in 25-30% of cases) neurologic deficit was noted in 5.0% of a series of 718 consecutive cases; 2.3% showed cerebellar ataxia, either as an isolated feature or in association with other lesions. The ataxia usually appeared in the ...

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Acute reversible cerebellar ataxia in typhoid fever.

Central nervous system involvement is not uncommonly seen in patients with enteric fever. However, acute cerebellar ataxia as an isolated neurological complication of enteric fever is very rare. We report a patient with blood culture proven enteric fever who developed acute cerebellar syndrome during the first week of illness. Following treatment with appropriate antibiotics, patient showed com...

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Pathogenesis of Lassa Fever

Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for hospitalized patients varying between 5-10%. Currently, there are no approved vaccines against Lassa fever for use in humans. Here, we review the publishe...

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Typhoid fever presenting as acute cerebellar ataxia and severe thrombocytopenia.

Typhoid fever being a systemic infection can present in a multitude of ways, involving various systems. Here we describe a case of typhoid fever presenting with acute cerebellar ataxia and marked thrombocytopenia. This atypical presentation is not common in typhoid fever and can lead to misdiagnosis as well as a delay in the initiation of appropriate therapy. Prompt clinical improvement and the...

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Lassa Fever, Nigeria, 2005–2008

To the Editor: Lassa fever affects ≈100,000 persons per year in West Af-rica (1). The disease is caused by Las-sa virus, an arenavirus, and is associated with bleeding and organ failure. The case-fatality rate in hospitalized patients is 10%–20%. The reservoir of the virus is multimammate mice (Mastomys natalensis). Investigations in the 1970s and 1980s pointed to the existence of 3 disease-end...

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ژورنال

عنوان ژورنال: Open Forum Infectious Diseases

سال: 2019

ISSN: 2328-8957

DOI: 10.1093/ofid/ofz512